Approximately 150 physicians, researchers, and allied health professionals attended the January 24, 2020 Clinical Climate Change Conference, representing more than 60 institutions across sectors. Now in its second year, the conference is convened by the Mount Sinai Institute for Exposomic Research, and this year’s partners included the American Lung Association, American Public Health Association, and the Center for Earth Ethics at Union Theological Seminary. Speakers included environmental justice advocates and leaders in the study of environmental medicine and public health, including a representative from TCEEE stakeholder advisory board (WE ACT) and TCEEE members Robert Wright, Nicholas DeFelice, Allan Just, Roberto Lucchini, Erin Thanik, Perry Sheffield, and Lauren Zajac. This CME event provided attendees with a base of up-to-date evidence to inform patient treatment and care, especially for vulnerable populations, including the elderly, children, and individuals who work outdoors. A patient education poster for health care settings was developed for the conference and distributed to attendees. Videos of key presentations are available at https://www.clinicalclimatechange.com/2020.